In many years this game is a huge one on the calendar, but both teams are disappointed with how 2021 has gone. Both teams enter with multiple losses at the midway point of the regular season and have more tough games ahead.

Florida led Vanderbilt 21-0 at half last before finishing off the shutout in a 42-0 win. But for 30 minutes, there were a lot of reasons to be concerned about the Gators. They gave up 200 yards, allowed the Commodores to convert 5-of-11 third downs, and committed five penalties. In the second half, UF came out much better, holding Vanderbilt to 87 yards while Emory Jones finished with 313 total yards and four passing touchdowns. The Gators opened as 10.5-point favorites for their road trip to LSU. Heading into a bye week followed by a neutral site game with Georgia, UF can’t afford to look ahead. It did that last year, and the Tigers stunned them in Gainesville.

LSU is not Vanderbilt. For one reason (among many others), the Tigers’ passing attack could keep things interesting at home against Florida, and their red zone offense is among the best in college football. LSU has lost back-to-back games, but there was a positive development from a 42-21 loss to Kentucky: Tyrion Davis-Price’s 147 rushing yards. The Tigers’ ground game was nonexistent before then, and it still ranks 127th among FBS teams, but that was a step in the right direction. Establish the run against Florida is one thing. Holding the Gators is another, and LSU has struggled to get stops.

These teams will meet at noon ET on ESPN.

Odds, Over/Under, Moneyline

Team Spread Total Moneyline

-11

58.5

-400

+310

Odds updated at 2:50 p.m. ET on Wednesday. Click here for live odds.

Florida-LSU storylines

‘This is not an opt-out’: Eli Ricks transfer rumors may be unfounded, but mounting injuries have LSU in trouble

Miller: The night the dam broke for Ed Orgeron

Gators stock report: Daquan Newkirk in coverage rises in value (if not frequency), along with RB vertical patterns

Expert picks against the spread

Picks made at Florida -10.

Pick

Dan Santaromita

Jason Starrett

Chris Vannini

Ari Wasserman

(Photo of Rick Wells: David Rosenblum / Icon Sportswire via Getty Images; The Athletic may receive an affiliate commission if you open an account with BetMGM through links contained in the above article.)

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